The incident occurred between junctions 17 and 16 on the southbound carriageway.
A speed limit of 40 mph was put in place as queues built up.
Images show traffic stretching into the distance from the incident.
The chaos broke out just before rush hour, disrupting commuters’ journeys home.
Two of four lanes were closed as a result of the crash.
There was reportedly four-and-a-half miles of congestion as a result.
Traffic monitoring site Inrix stated: “Two lanes closed, queueing traffic and speed restriction of 40 mph due to accident, three vehicles involved on M6 Southbound between J17 A534 Old Mill Road (Sandbach / Crewe) and J16 A500 (Stoke-On-Trent / Crewe).”
This was later updated to confirm that the lanes have been reopened.
However, there remains two miles of congestion on approach.
Drivers are advised to allow extra time for this to clear.
Today’s crash comes just three days after the M6 northbound towards Lancashire was hit with huge traffic queues following a crash.
The queues reportedly stretched for over seven miles.
Two lanes were closed on the northbound M6 near junction 25 for Bryn following the crash at around 3.30pm Friday (June 10).
The delays in this instance lasted for more than an hour.
National Highways deals with almost 180 reported incidents on the M6 every day.
These include a large number of traffic collisions, with 3,484 reported on the M6 in 2021 – despite the impact of lockdown at the start of the year.
The motorway was labelled the most dangerous in the UK in 2018 after research showed it claimed more than a dozen lives each year on average in the preceding decade.
Also the longest motorway, 160 deaths were recorded on the M6 between 2007 and 2016, with 7,342 accidents reported.